RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Taz
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Collection and Analysis of Expression Array Data; In situ hybridization etc.
Target
NA
Pathway
NA
PubMed ID
Title
A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions
Year
2015
Function
"MiR-130/301 expression correlates with activation of YAP/TAZ, the PPARY-APOE-LRP8 axis, and matrix stiffening in pulmonary fibrosis and liver fibrosis. Forced miR-130/301 expression activates ECM remodeling and liver fibrosis in mice. Inhibition of the miR-130/301 family prevents ECM remodeling and disease progression in mouse models of pulmonary fibrosis and liver fibrosis. Mechanical forces act through a central feedback circuit between microRNA-130/301 and YAP/TAZ to sustain a common fibrotic phenotype across a network of human physiologic and pathophysiologic states."